Dr. Laura Frieboes serves as an Adjunct Professor at Holy Apostles College & Seminary in Cromwell, CT. Dr. Frieboes has a Ph.D. in Biomedical Engineering from the University of California Irvine. Her dissertation focused on mechanotransduction and signaling in the peripheral nervous system related to chronic compressive neuropathies (e.g., carpal tunnel syndrome). She also holds a B.A. in Physics from Lewis and Clark College and a B.S. in Biomedical Engineering/ Biomechanics from Columbia University. For the past several years, Dr. Frieboes and her husband have been involved in adult education, offering presentations and courses on various topics including relationship between science and religion, ethics in business and the workplace, current medical issues, and bioethics.

Education

• University of California Irvine, Ph.D. Biomedical Engineering, Irvine, CA
• University of California Irvine, M.S. Biomedical Engineering, Irvine, CA
• Columbia University, B.S. Biomedical Engineering, New York, New York, (Biomechanics)
• Lewis and Clark College, B.A. Physics, Portland, OR

Representative Publications – Scientific Papers

• Rummler, LR; Gupta, R: Peripheral nerve repair: a review. Current Opinion in Orthopaedics 15(4): 215-219, 2004.
• Rummler, LS; Dinh, PT; Gupta, R. The anatomy and biochemistry of myelin and myelination. Operative Techniques in Orthopaedics 14(3):146-152, 2004.
• Gupta, R; Rummler, L; Steward, O. Understanding the biology of compressive neuropathies. Clinical Orthopaedics and Related Research 436:251-260, June, 2005.
• Gupta, R; Rummler, LS; Palispis, W; Chao, T; Truong, L; Steward, O. Local down-regulation of myelin-associated glycoprotein permits axonal sprouting with chronic nerve compression injury. Experimental Neurology 200(2): 418-29, 2006.
• Frieboes, LR; Gupta, R. An in vitro traumatic model to evaluate the response of myelinated cultures to sustained hydrostatic compression injury. Journal of Neurotrauma 26(12):2245-56, 2009.
• Frieboes, LR; Palispis, WA; Gupta, R. Nerve Compression Activates Selective Nociceptive Pathways and Upregulates Peripheral Sodium Channel Expression in Schwann Cells. Journal of Orthopaedic Research 28(6):753-61, 2010.
• Lin MY, Frieboes LR, Forootan M, Palispis WA, Mozaffar T, Jafari M, Steward O, Gall CM, Gupta R. Biophysical stimulation induces demyelination via an integrin-dependent mechanism. Ann Neurol. 2012 Jul;72(1):112-23.

Representative Publications – Scientific Conference Abstracts

• Gray, M; Modafferri, E; Chao, T; Rummler, L; Jones, NF; Mozzaffar, T; Steward, O; Gupta, R. The role of vascular endothelial growth factor and its receptors in carpal tunnel syndrome. Transactions of the Plastic Surgery Research Council 48: 137, April 2003.
• Chao, T; Bui, P; Gray, M; Rummler, L; Jones, NF; Mozzaffar, T; Gupta, R. Chronic nerve compression induces aberrant axonal sprouting. Transactions of the Plastic Surgery Research Council 48: 194, April 2003.
• Rummler, LS; Chao, T; Steward, O; Gupta, R. Evaluation of Pain in an Animal Model for Compression Neuropathy. Transactions of the American Society for Peripheral Nerve14:57-58, 2004.
• Gray, M; Modafferi, E; Chao, T; Bear, D; Rummler, LS; Mozaffar, T; Steward, O; Gupta, R: Schwann Cell Production of Vascular Endothelial Growth Factor (VEGF) in a Model for Carpal Tunnel Syndrome. Transactions of the Orthopaedic Research Society 29:915, 2004.
• Rummler, LS; Chao, T; Steward, O; Gupta, R. Evaluation of Pain in Model for Compressive Neuropathies. Transactions of American Society for Surgery of the Hand 59:82, 2004.
• Gupta, R; Chao, T; Rummler, LS; Truong, L; Steward, O. Immunolocalization of Pain-Mediating Fibers with Chronic Nerve Compression Injury. Proceedings of the Society for Neuroscience 34:858.4, 2004.
• Truong, LN; Rummler, L; Bear, D; Hung, CT; Gupta, R. Shear stress alters the expression of myelin associated glycoprotein and myelin basic protein in Schwann cells. Transactions of the Orthopaedic Research Society 30: 225, 2005.
• Rummler, LS; Chao, T; Steward, O; Gupta, R. Evaluation of pain in an animal model for compressive neuropathies. Transactions of the Orthopaedic Research Society 30: 537, 2005.
• Gupta R, Rummler L, Palispis W, Truong L, Chao T, Rowshan K, Steward O. Local down-regulation of myelin associated glycoprotein permits axonal sprouting after chronic nerve compression injury. Journal of the Peripheral Nervous System 10(S1):31, July 2005.
• Bear, D; Rummler, LS; Gupta, R. The pain of carpal tunnel syndrome occurs secondary to localized ion channel migration. Journal of the Peripheral Nervous System 10(S1):4, July 2005.
• Bear, D; Rummler, L; Chao, T; Mozaffar, T; Gupta, R. The pain of carpal tunnel syndrome may occur secondary to localized ion channel migration. Transactions of the 23rd Annual Adrian E. Flatt Residents and Fellows Conference in Hand Surgery. 23:24, 2005.
• Gupta, R; Rummler, LS; Palispis, W; Truong, L; Chao, T; Rowshan, K; Mozaffar, T; Steward, O. Local down-regulation of myelin associated glycoprotein permits axonal sprouting after chronic nerve compression injury. Transactions of the Eleventh International Symposium on Neural Regeneration 11:41, 2005.
• Bear, D; Rummler, L; Chao, T; Mozaffar, T; Gupta, R. Localized ion channel migration after neural injury mediates pain. Transactions of the Orthopaedic Research Society 31:1868, 2006.
• Rummler, LS; Palispis, W; Truong, LN; Chao, T; Rowshan, K; Steward, O; Gupta R. Local down-regulation of myelin associated glycoprotein permits axonal sprouting after chronic nerve compression injury. Transactions of the Orthopaedic Research Society 31:1871, 2006.
• Rummler, LS; Palispis, W; Gupta, R: Mechanisms of pain in an in vivo model for chronic nerve compression injury. Transactions of the Society for Neuroscience 383.1, 2006.
• Rummler, L; Palispis, W; Gupta, R. Schwann cells up-regulate NaV1.8 after chronic nerve injury. Transactions of the Sunderland Society 16: 4, 2007.
  Rummler, LS; Palispis, WA; Gupta, R. Schwann cells up-regulate NaV1.8 after chronic nerve injury. Journal of Peripheral Nervous System 12 (S1): 72, July, 2007.
• Rummler, LS; Palispis, W; Gupta, R. The Pain of Chronic Nerve Injuries May Be Mediated by Schwann Cells (Paper 42). Transactions of the American Society for Surgery of the Hand 62: 664, 2007.
• Rummler, LS; Palispis, W; Gupta, R. Understanding the pain associated with Chronic Nerve Compression Injuries. Transactions of the American Society for Peripheral Nerve. Page 42, 2008.
• Rummler, L; Palispis, W; Gupta, R. The pain of carpal tunnel syndrome is likely mediated by Schwann cells. Transaction of the Orthopaedic Research Society 54: 367, 2008.
• Rummler, L; Palispis, W; Tapadia, M; Gupta, R. Application of Hydrostatic Compression Force Induces Schwann Cell Proliferation In Vitro. Transaction of the Orthopaedic Research Society, 2009.
• Nassiri, N; Pham, K; Tapadia, M; Rummler, L; Gupta, R. ß4 Integrin localization at Schmidt-Lanterman incisures following chronic nerve injury. Transaction of the Orthopaedic Research Society, 2009.
• Pham, K; Tapadia, M; Nassiri, N; Rummler, L; Hazel, A; Gupta, R. Transcriptional Regulation of Integrin-Mediated Demyelination Following Chronic Nerve Injury. Transaction of the Orthopaedic Research Society, 2009.
• Bathen, M; Hazel, A; Palispis, W; Rummler, L; Strandberg, E; Mozaffar, T; Gupta, R. Development of a Novel Murine Model of Primary Demyelinating Neuropathy. Transaction of the Orthopaedic Research Society, 2009.
• Smith, J; Pham, T; Anderson, R; Rummler, L; Bhatia, N; Steward, O; Gupta, R. The role of decompression with either durotomy or duraplasty following cervical spinal cord injury. Transaction of the Orthopaedic Research Society, 2009.